Apicomplexan Energy Metabolism: Carbon Source Promiscuity and the Quiescence Hyperbole

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• 作者：Damien Jacot¹ ; Ross F. Waller² ; Dominique Soldati-Favre¹ ; Dougal A. MacPherson³ ; James I. MacRae⁴ ; ^{james.macrae@crick.ac.uk" class="auth_mail" title="E-mail the corresponding author}
• 关键词：metabolism ; Plasmodium ; Toxoplasma ; mitochondrion ; TCA cycle ; Apicomplexa
• 刊名：Trends in Parasitology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：32
• 期：1
• 页码：56-70
• 全文大小：3422 K

文摘

The nature of energy metabolism in apicomplexan parasites has been closely investigated in the recent years. Studies in Plasmodium spp. and Toxoplasma gondii in particular have revealed that these parasites are able to employ enzymes in non-traditional ways, while utilizing multiple anaplerotic routes into a canonical tricarboxylic acid (TCA) cycle to satisfy their energy requirements. Importantly, some life stages of these parasites previously considered to be metabolically quiescent are, in fact, active and able to adapt their carbon source utilization to survive. We compare energy metabolism across the life cycle of malaria parasites and consider how this varies in other apicomplexans and related organisms, while discussing how this can be exploited for therapeutic intervention in these diseases.