CYB5D2 displays tumor suppression activities towards cervical cancer
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- 作者：Yanyun Xiea ; b ; c ; d ; 1 ; Yen Ting Shenb ; c ; d ; 1 ; Anil Kapoorc ; e ; Diane Ojob ; c ; d ; Fengxiang Weif ; g ; Jason De Melob ; c ; d ; Xiaozeng Linb ; c ; d ; Nicholas Wongb ; c ; d ; Judy Yanb ; c ; d ; Lijian Taoa ; Pierre Majorh ; Damu Tangb ; c ; d ; damut@mcmaster.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：CYB5D2 ; Tumor suppressor ; Cervical cancer ; Xenograft tumors ; Metastasis
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1862
- 期：4
- 页码：556-565
- 全文大小：2615 K
文摘
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CYB5D2 is a novel tumor suppressor by suppressing cervical cancer tumorigenesis.
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CYB5D2 inhibits HeLa cell invasion in vitro and lung metastasis in vivo.
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CYB5D2 is reduced in 85% of primary squamous cell carcinomas of the cervix.
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CYB5D2 suppresses cervical cancer independently of its association with heme.