Nonsense-Mediated Decay Restricts LncRNA Levels in Yeast Unless Blocked by Double-Stranded RNA Structure
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- 作者：Maxime Wery1 ; Marc Descrimes1 ; Nicolas Vogt1 ; Anne-Sophie Dallongeville1 ; Daniel Gautheret2 ; daniel.gautheret@u-psud.fr" class="auth_mail" title="E-mail the corresponding author ; Antonin Morillon1 ; antonin.morillon@curie.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：lncRNA ; Xrn1 ; NMD ; dsRNA ; RNA helicases
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：4 February 2016
- 年：2016
- 卷：61
- 期：3
- 页码：379-392
- 全文大小：3499 K
文摘
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Xrn1-sensitive Unstable Transcripts (XUTs) are 3′-extended isoforms of stable lncRNAs
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Nonsense-Mediated Decay preferentially targets long XUTs with single-stranded 3′ end
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Antisense XUTs form double-stranded RNA in vivo
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Formation of double-stranded RNA protects XUTs from Nonsense-Mediated Decay