Programming of Intestinal Epithelial Differentiation by IL-33 Derived from Pericryptal Fibroblasts in Response to Systemic Infection
详细信息 查看全文
- 作者：Mousumi Mahapatro1 ; Sebastian Foersch1 ; Manuela Hefele1 ; Gui-Wei He1 ; Elisa Giner-Ventura2 ; Tamar Mchedlidze1 ; Markus Kindermann1 ; Stefania Vetrano3 ; Silvio Danese3 ; Claudia Gü ; nther1 ; Markus F. Neurath1 ; Stefan Wirtz1 ; 4 ; Christoph Becker1 ; 4 ; christoph.becker@uk-erlangen.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：24 May 2016
- 年：2016
- 卷：15
- 期：8
- 页码：1743-1756
- 全文大小：5914 K
文摘
- •
IL-33 signaling to intestinal epithelial cells protects against Salmonella infection
- •
IL-33 is released by pericryptal fibroblasts in the small intestine
- •
IL-33 directly stimulates intestinal stem and progenitor cells via the ST2 receptor
- •
IL-33 inhibits Notch signaling, promoting the differentiation of secretory IEC