- 作者：Bruce S. Shapiro ; M.D. ; Ph.D.a ; b ; bsshapiro@aol.com ; Said T. Daneshmand ; M.D.a ; b ; Laura De Leon ; M.D.b ; Forest C. Garner ; M.Sc.a ; b ; Martha Aguirre ; Ph.D.a ; Cynthia Hudson ; M.S.a
- 关键词：Ectopic pregnancy ; assisted reproduction ; ovarian stimulation ; embryo cryopreservation
- 刊名：Fertility and Sterility
- 出版年：2012
- 出版时间：December, 2012
- 年：2012
- 卷：98
- 期：6
- 页码：1490-1494
- 全文大小：118 K
Objective
To compare the incidence of ectopic pregnancy (EP) after fresh ET and thawed ET.Design
Retrospective cohort study.
Setting
Private fertility center.
Patient(s)
This retrospective study included 2,150 blastocyst transfers, including all 1,460 fresh autologous blastocyst transfers and all 690 transfers of autologous blastocysts derived from post-thaw extended culture of thawed bipronuclear oocytes in the 8-year study period 2004-2011.
Intervention(s)
None.
Main Outcome Measure(s)
Visualized EP and treated persistent pregnancy of unknown location.
Result(s)
The rate of visualized EP was 1.5 % in pregnancies in fresh autologous cycles, which was significantly more than the rate of 0 with autologous post-thaw extended culture. The rates of treated persistent pregnancy of unknown location were 2.5 % and 0.3 % in these two groups, respectively, a difference that was also statistically significant (relative risk 7.3, 95 % confidence interval 1.7-31.0).
Conclusion(s)
Relative to fresh transfer, thawed ET was associated with significantly reduced incidence of EP. These findings are consistent with ovarian stimulation increasing the risk of EP.