Rôle des cytokines dans les pathologies auto-immunes : Apport des modèles murins transgéniques

详细信息    查看全文

• 作者：Scott-Algara ; Daniel ; Dighiero ; Guillaume ; Guenounou ; Moncef
• 关键词：Souris transgé ; niques - maladies auto-immunes - cytokines ; Transgenic mice - autoimmune diseases - cytokines
• 刊名：Revue Francaise des Laboratoires
• 出版年：2000
• 出版时间：December, 2000
• 年：2000
• 卷：2000
• 期：328
• 页码：57-60
• 全文大小：704 K

文摘

The autoimmune responses are under the control of the very complex immunological regulating circuits. Many autoimmune diseases involve an imbalance of cytokines. Recent work stressed that factors controlling the autoimmunity can act either by increasing a normal immune response, or by inhibiting the normal response, this dependent on the site and the synchronization of the initial action of cytokines during normal immune response. In a review article by Marika Falcone and Nora Sarvetnick, the state of art in the role of cytokines in autoimmune diseases is discussed. Recent works in this very complex field partially discovered the mechanisms by which the molecules of regulation take part in the appearance of the autoimmune processes. The production of IL-12 in absence of infection can predispose to autoimmune diseases. The transforming growth factor beta (TGF-β) and IL-4 can remove an autoimmune response induced by self reactive T cells. The pro-inflammatory cytokines can improve the phenomena related to the autoimmunity, dependent on their synchronization of secretion and their level of production. Moreover, cytokines can modulate autoimmune response by acting on antigen presenting cells (macrophages or dendritic cells). Learning more about the molecular mechanisms involved in the regulation of cytokine secretion may able to develop novel therapeutic agents in order to protect against cytokine mediated immunopathology.