In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring
详细信息 查看全文
- 作者：Alice Hartmann dos Santosa ; Milene Leivas Vieiraa ; Nathá ; lia de Azevedo Camina ; Janete Aparecida Anselmo-Francib ; Graziela Scalianti Ceravoloa ; Gislaine Garcia Pelosia ; Estefâ ; nia Gastaldello Moreiraa ; Ana Carolina Inhasz Kissc ; Suzana de Fá ; tima Paccola Mesquitad ; Daniela Cristina Ceccatto Gerardina ; dcgerardin@uel.br" class="auth_mail" title="E-mail the corresponding author ; danigerardin@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-HT ; serotonin ; DA ; dopamine ; NA ; noradrenaline ; GABA ; gamma-aminobutyric acid ; CTR ; control ; FLX ; fluoxetine ; SSRIs ; selective serotonin reuptake inhibitors ; GD ; gestational day ; LD ; lactational day ; PND ; postnatal day ; AGD ; anogenital distance ; VO ; vaginal opening ; HPG axis ; hypothalamic-pituitary-gonadal axis ; GnRH ; gonadotropin release hormone ; LH ; luteinizing hormone ; FSH ; follicle stimulating hormone ; LM ; lordosis magnitude ; LQ ; lordosis quotient ; MB ; maternal behavior ; ANCOVA ; analysis o
- 刊名：Reproductive Toxicology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：62
- 期：Complete
- 页码：1-8
- 全文大小：878 K
文摘
- •
Maternal exposure to Fluoxetine (FLX) during pregnancy and lactational periods did not affect the maternal and offspring toxicity parameters evaluated.
- •
In utero and lactational exposure to FLX delayed puberty onset in female offspring.
- •
Developmental exposure to FLX did not change the reproductive and morphological parameters analyzed in female offspring during adulthood.