Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs
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- 作者：Damir Jacob Illich1 ; 2 ; 11 ; Miao Zhang1 ; 11 ; Andrei Ursu2 ; 4 ; 11 ; Rodrigo Osorno1 ; Kee-Pyo Kim1 ; Juyong Yoon1 ; Marcos J. Araú ; zo-Bravo1 ; 3 ; 12 ; Guangming Wu1 ; Daniel Esch1 ; Davood Sabour1 ; 13 ; Douglas Colby10 ; Kathrin S. Grassme5 ; Jiayu Chen6 ; Boris Greber7 ; 8 ; Susanne Hö ; ing1 ; Wiebke Herzog1 ; 5 ; 9 ; Slava Ziegler2 ; Ian Chambers10 ; Shaorong Gao6 ; Herbert Waldmann2 ; 4 ; herbert.waldmann@mpi-dortmund.mpg.de" class="auth_mail" title="E-mail the corresponding author ; Hans R. Schö ; ler1 ; 5 ; office@mpi-muenster.mpg.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：26 April 2016
- 年：2016
- 卷：15
- 期：4
- 页码：787-800
- 全文大小：4688 K
文摘
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Inhibition of CK1alpha induces ESC conversion in EpiSCs recalcitrant to 2i/LIF
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The ESC conversion acts via WNT activation and TGFbeta/SMAD2 inhibition
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MEK inhibition stabilizes the conversion and restores germline competence
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CK1 inhibition promotes activation and maintenance of the pluripotency network