Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability
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- 作者：M. Catarina Silva1 ; Chialin Cheng1 ; Waltraud Mair2 ; Sandra Almeida3 ; Helen Fong4 ; M. Helal U. Biswas3 ; Zhijun Zhang3 ; Yadong Huang4 ; Sally Temple5 ; Giovanni Coppola6 ; Daniel H. Geschwind6 ; Anna Karydas7 ; Bruce L. Miller7 ; Kenneth S. Kosik8 ; Fen-Biao Gao3 ; Judith A. Steen2 ; Stephen J. Haggarty1 ; shaggarty@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：13 September 2016
- 年：2016
- 卷：7
- 期：3
- 页码：325-340
- 全文大小：6687 K
文摘
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Upregulation of tau and phospho-tau in FTD patient iPSC-derived tau A152T neurons
Upregulation of insoluble tau in A152T neurons
Altered proteostasis stress-inducible pathways in tau A152T neurons
Tau-dependent vulnerability to stress in A152T neurons reverted by tau downregulation