Abnormal Development of the Earliest Cortical Circuits in a Mouse Model of Autism Spectrum Disorder

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• 作者：Daniel A. Nagode¹ ; Xiangying Meng¹ ; Daniel E. Winkowski¹ ; Ed Smith¹ ; Hamza Khan-Tareen¹ ; Vishnupriya Kareddy¹ ; Joseph P.Y. Kao² ; Patrick O. Kanold¹ ; ³ ; ^{pkanold@umd.edu}
• 关键词：subplate ; autism ; cortex ; development ; valproate
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：31 January 2017
• 年：2017
• 卷：18
• 期：5
• 页码：1100-1108
• 全文大小：3107 K
• 卷排序：18

文摘

Prenatal VPA exposure alters excitatory and inhibitory connectivity in the subplate VPA exposure induces laminar-dependent hyperconnectivity to subplate Fine-scale spatial analysis reveals “patches” of altered connectivity after VPA VPA alters excitatory-inhibitory balance of subplate circuits