Synthesis, characterisation and antimicrobial studies of organotin(IV) complexes with 1,10-phenanthroline derivatives

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• 作者：Niamh Dolan ; John McGinley ; John C. Stephens ; Kevin Kavanagh ; Daniel Hurley ; Niall J. Maher
• 关键词：Organotin halides and acetates ; 1 ; 10-Phenanthroline derivatives ; NMR studies ; Biological testing
• 刊名：Inorganica Chimica Acta
• 出版年：1 January, 2014
• 年：2014
• 卷：409
• 期：part_PB
• 页码：276-284
• 全文大小：1425 K

文摘

The synthesis of several diorganotin(IV) dicarboxylate compounds, including acetates and nicotinates as well as diorganotin(IV) dichloride complexes of the ligands phen, dione and dppz were undertaken. Several difficulties in either the syntheses or complexation reactions with the organic ligands were encountered. The diorganotin(IV) dichloride complexes of the ligands (R₂SnCl₂路L where R = Me, n-Bu or Ph and L = phen, dione or dppz) were tested against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The dibutyltin(IV) derivatives exhibited the broadest range of activity in comparison to the dimethyltin(IV) or diphenyltin(IV) derivatives. The addition of the nicotinate group did not promote activity against any of the bacteria. Furthermore, only in the case of Ph₂SnCl₂路dione was there improved activity compared to the organic ligand itself.