Stigmurin and TsAP-2 from Tityus stigmurus scorpion venom: Assessment of structure and therapeutic potential in experimental sepsis
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- 作者：Alessandra Daniele-Silvaa ; Richele J.A. Machadoa ; b ; Norberto K.V. Monteiroc ; André ; ia B. Estrelaa ; Elizabeth C.G. Santosa ; Eneas Carvalhod ; Raimundo F. Araú ; jo Jú ; niore ; Raniere F. Melo-Silveirab ; Hugo Alexandre O. Rochab ; Arnó ; bio A. Silva-Jú ; niora ; Matheus F. Fernandes-Pedrosaa ; b ; mpedrosa@ufrnet.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Scorpion ; Structural assessment ; Antimicrobial peptides ; Antiproliferative ; Sepsis
- 刊名：Toxicon
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：10-21
- 全文大小：2941 K
文摘
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Tityus stigmurus venom encode a peptide with mature amino acid sequence identical to TsAP-2 from T. serrulatus.
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TsAP-2 changed its secondary structure depending on the polarity of the environment.
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Stigmurin and TsAP-2 were stable to temperature and pH variation in the presence of SDS.
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Stigmurin and TsAP-2 showed antimicrobial activity in vitro and ex vivo.
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Stigmurin and TsAP-2 were effective to reduce microbial load and inflammation in experimental sepsis.