Fluvoxamine maleate normalizes striatal neuronal inflammatory cytokine activity in a Parkinsonian rat model associated with depression
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- 作者：Ernest Dallé ; Willie M.U. Daniels ; Musa V. Mabandla ; mabandlam@ukzn.ac.za" class="auth_mail" title="E-mail the corresponding author ; 212561283@stu.ukzn.ac.za" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fluvoxamine maleate ; Depression ; Inflammatory cytokines ; Striatum ; Parkinson&rsquo ; s disease
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：316
- 期：Complete
- 页码：189-196
- 全文大小：1461 K
文摘
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Early maternal separation caused anhedonia and exacerbated the effects of 6-OHDA in lesioned rats.
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Fluvoxamine reversed the effects of 6-OHDA lesion by modulating cytokine gene expression in the striatum of treated rats.
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Fluvoxamine normalized pro- and anti-inflammatory cytokine expression in the striatum of treated rat.