Dissociation of Survival, Proliferation, and State Control in Human Hematopoietic Stem Cells

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• 作者：David J.H.F. Knapp¹ ; Colin A. Hammond¹ ; Paul H. Miller¹ ; Gabrielle M. Rabu¹ ; Philip A. Beer¹ ; Marketa Ricicova² ; Vé ; ronique Lecault² ; ³ ; Daniel Da Costa² ; ³ ; Michael VanInsberghe³ ; Alice M. Cheung¹ ; Davide Pellacani¹ ; James Piret⁴ ; Carl Hansen³ ; Connie J. Eaves¹ ; ^{ceaves@bccrc.ca}
• 关键词：human ; hematopoietic stem cell ; HSC ; growth factor ; survival ; apoptosis ; cell death ; proliferation ; mitogenesis ; self-renewal ; microfluidics ; transplantation ; xenotransplantation
• 刊名：Stem Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：8
• 期：1
• 页码：152-162
• 全文大小：902 K
• 卷排序：8

文摘

Growth factors alone can maintain serially transplantable human cord blood HSCs Growth factors tunably and combinatorially control HSC survival and proliferation SCF is a critical factor for stimulating human HSC proliferation HSC regenerative activity is regulated independent of HSC survival or proliferation