Preparation of the even-numbered 3-oxo fatty acid nicotinyl esters from C6:0 to C18:0

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• 作者：Daniela Sieben ; Alexander Santana ; Paul Nowka ; Sven Weber ; Kai Funke ; Stefan H. Hü ; ttenhain ; ^{stefan.huettenhain@h-da.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Fatty acid esters ; β-Ketoesters ; Transesterification ; Nicotinyl ester
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：17 February 2016
• 年：2016
• 卷：57
• 期：7
• 页码：808-810
• 全文大小：357 K

文摘

Here, we report a systematic comparison of different methods for the transesterification of 3-oxo fatty acid alkyl esters to the corresponding nicotinyl esters. A simple method producing the target esters in high yields and purity has been developed. Nicotinyl esters are of interest for mass spectrometry analysis of fatty acids. Also, the hydrophilic head group of nicotinyl esters can be used as the basis for the preparation of liposome-building molecules.