NF-κB localization in multiple myeloma plasma cells and mesenchymal cells
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- 作者：Concetta Conticello ; Raffaella Giuffrida ; Luana Adamo ; Gabriele Anastasi ; Daniela Martinetti ; Edvige Salomone ; Cristina Colarossi ; Gabriella Amato ; Ausilia Gorgone ; Aless ; ra Romano ; Gioacchin Iannolo
- 关键词：Multiple myeloma ; NF-κ ; B ; Bortezomib ; Mesenchymal cells
- 刊名：Leukemia Research
- 出版年：2011
- 出版时间：January 2011
- 年：2011
- 卷：35
- 期：1
- 页码：52-60
- 全文大小：1220 K
文摘
Several reports demonstrated that the activation of Nuclear Factor-kappa B NF-κB is essential for the pathogenesis of multiple myeloma (MM). We analyzed the nuclear localization of NF-κB in MM-cells derived from 60 different patients with MM at presentation and in relapse, as well as in three myeloma cell lines. Nuclear localization (the active form) of NF-κB was detected in only one MM-sample from a refractory patient and in two samples from relapsed patients, while all the other samples, including the MM-cell lines, almost exclusively express the cytoplasmic (inactive) form of NF-κB. In mesenchymal cells from MM-patients NF-κB was clearly present in the nucleus. In addition, the proteasome inhibitor Bortezomib, which is described to antagonize NF-κB activity, had a consistent antitumor activity against both chemoresistant and chemosensitive MM-cells, regardless the NF-κB localization, thus suggesting the existence of other molecular targets of proteasome inhibitors in MM.