Activity of vancomycin release from bioinspired coatings of hydroxyapatite or TiO₂ nanotubes

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• 作者：Daniela Ionita^a ; Daniela Bajenaru-Georgescu^a ; Georgeta Totea^b ; Anca Mazare^c ; ^{anca.mazare@fau.de} ; ^{anca.mazare@gmail.com} ; Patrik Schmuki^c ; Ioana Demetrescu^a
• 关键词：Hydroxyapatite ; TiO2 nanotubes ; Hydroxyapatite-collagen coatings ; Vancomycin ; S. aureus
• 刊名：International Journal of Pharmaceutics
• 出版年：2017
• 出版时间：30 January 2017
• 年：2017
• 卷：517
• 期：1-2
• 页码：296-302
• 全文大小：2542 K
• 卷排序：517

文摘

Herein we investigate the efficiency of various biomimetic coatings for localized drug delivery, using vancomycin as key therapeutic drug, which is a widely used antibiotic for the treatment of strong infections caused by positive Gram bacteria. We evaluate classical hydroxyapatite and biomimetic hydroxyapatite-collagen coatings obtained by electrochemical deposition as well as TiO2 nanotubes arrays obtained by electrochemical anodization. Surface morphology, compositional and structural data confirm the incorporation of vancomycin into the layers and drug release profiles for vancomycin evaluate their release ability. Namely, hydroxyapatite coatings lead to a ≈92% vancomycin release after 30 h and hydroxyapatite-collagen to 85%, while the TiO2 nanotubes layers lead to 78% release. The antibacterial effect of such drug loaded coatings is evaluated against S. aureus (Gram-positive bacteria). Our study shows that the vancomycin incorporated hydroxyapatite coatings lead to a faster release, while the nanotubular coatings may lead to longer time release and additionally both types of coatings ensure a good antibacterial inhibition.