Unravelling cortico-hypothalamic pathways regulating unconditioned fear-induced antinociception and defensive behaviours

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• 作者：Luiz Luciano Falconi-Sobrinho^a ; Tayllon dos Anjos-Garcia^a ; Daoud Hibrahim Elias-Filho^a ; Norberto Cysne Coimbra^a ; ^b ; ^{nccoimbr@fmrp.usp.br}
• 关键词：Panic attacks ; Unconditional fear-induced antinociception ; Anterior cingulate cortex ; Posterior hypothalamus ; AMPA/kainate receptors ; NMDA receptors
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：367-385
• 全文大小：4653 K
• 卷排序：113

文摘

Lidocaine in ACC decreased the proaversive effect and antinociception evoked by bicuculline in PH. NBQX in PH attenuated anxiety- and panic-like defensive reaction and antinociception. LY235959 in PH attenuated panic-like defensive reactions and antinociception. ACC modulates defensive behaviour and antinociception organised by PH neurons. Glutamatergic efferent pathways from the ACC to the PH modulate fear-induced defensive responses.