Chemical structures, biosynthesis, bioactivities, biocatalysis and semisynthesis of tobacco cembranoids: An overview
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- 作者：Ning Yan ; Yongmei Du ; Xinmin Liu ; Hongbo Zhang ; Yanhua Liu ; Peng Zhang ; Daping Gong ; Zhongfeng Zhang ; zhangzhongfeng@caas.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：8-OH-CPP ; 8-α-hydroxy-copalyl-pyrophosphate ; AChRs ; acetylcholine receptors ; AIDS ; acquired immunodeficiency syndrome ; CBT-diol ; cembratrien-diol ; CBT-ol ; cembratrien-ol ; CBTS ; cembrantrien-ol synthase ; CDK ; cyclin-dependent protein kinase ; CYP450 ; cytochrome P450 hydroxylase ; DMAPP ; dimethylallyl diphosphate ; DFP ; diisopropylfluorophosphate ; EA ; early antigen ; EBV ; Epstein&ndash ; Barr virus ; EC50 ; concentration for 50% of maximal effect ; ERK ; extracellular signal regulated kinase-1 ; 2 ; GGPP ; gera
- 刊名：Industrial Crops & Products
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：83
- 期：Complete
- 页码：66-80
- 全文大小：3199 K
文摘
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Cembranoids are mainly found in plants of the Nicotiana and Pinus genera, as well as in soft coral and other marine organisms.
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We summarise the chemical structures and biosynthetic pathways of tobacco cembranoids, and factors influencing their accumulation.
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Tobacco cembranoids are known to display antimicrobial, anti-tumour and neuroprotective properties, which make them excellent templates for the future development of drugs to treat AIDS, cancer and neurodegenerative diseases.
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A large number of bioactive compounds have been prepared from the biocatalysis and semisynthesis of tobacco cembranoids.