Dapper-1 is essential for Wnt5a induced cardiomyocyte hypertrophy by regulating the Wnt/PCP pathway
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- 作者：Marco Hagenmuellera ; Johannes H. Riffela ; Elmar Bernholda ; Jingjing Fana ; Hugo A. Katusa ; b ; Stefan E. Hardta ; b ; stefan.hardt@med.uni-heidelberg.de" class="auth_mail
- 关键词：PCP ; planar cell polarity ; Vangl2 ; Van Gogh like 2
- 刊名：FEBS Letters
- 出版年：27 June 2014
- 年：2014
- 卷：588
- 期：14
- 页码：2230-2237
- 全文大小：1910 K
文摘
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Wnt5a stimulation induces cardiomyocyte hypertrophy.
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Knockdown of Dpr1 blocks Wnt5a induced cardiomyocyte hypertrophy.
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Dpr1 is required for Wnt5a mediated activation of JNK.
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Dpr1 depletion leads to accumulation of Vangl2 in perinuclear located vesicles.
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Members of the Wnt/PCP pathway are upregulated in the remote area of the left ventricle in a rat myocardial infarction model.