Effects of neonatal allopregnanolone manipulations and early maternal separation on adult alcohol intake and monoamine levels in ventral striatum of male rats
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- 作者：Anna Llidó ; Iris Bartolomé ; Sò ; nia Darbra ; Marc Pallarè ; s ; marc.pallares@uab.cat" class="auth_mail" title="E-mail the corresponding author
- 关键词：Allopregnanolone ; Finasteride ; Early maternal separation ; Ethanol consumption ; Dopamine ; Serotonin ; Ventral striatum
- 刊名：Hormones and Behavior
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：82
- 期：Complete
- 页码：11-20
- 全文大小：996 K
文摘
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Neonatal finasteride increases alcohol and glucose intake in adulthood.
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Early maternal separation increases alcohol intake in neonatal vehicle injected rats.
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Neonatal neurosteroid manipulation effects depend on maternal separation condition.
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Neonatal finasteride/allopregnanolone decreases ventrostriatal dopamine and serotonin.
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Subsequent early maternal separation restores the dopamine and serotonin levels.