The prognostic significance of troponin I elevation in acute ischemic stroke

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• 作者：Omar Batal ; MD^a ; Jacob Jentzer ; MD^a ; Bhavna Balaney ; MD^b ; Nadeem Kolia ; MD^c ; Gavin Hickey ; MD^a ; Zeina Dardari ; MS^d ; Vivek Reddy ; MD^e ; Tudor Jovin ; MD^e ; Maxim Hammer ; MD^e ; John Gorcsan ; MD^a ; Mark Schmidhofer ; MD^a ; ^{schmidhoferm@upmc.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Acute ischemic stroke ; Coronary artery disease ; Myocardial infarction ; Cardiac troponin
• 刊名：Journal of Critical Care
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：31
• 期：1
• 页码：41-47
• 全文大小：423 K

文摘

The significance of cardiac troponin I (TnI) levels in patients with acute ischemic stroke remains unclear.

Methods

Data were prospectively collected on 1718 patients with acute ischemic stroke (2009-2010). Patients with positive TnI (peak TnI ≥ 0.1 μg/L) were assigned to the myocardial infarction (MI) group if they met diagnostic criteria. The remaining patients with positive TnI were assigned to the no-MI group. Patients were followed up for 1.4 ± 1.1 years. Primary outcome was inhospital and long-term all-cause mortality.

Results

Positive TnI was present in 309 patients (18%), 119 of whom (39%) were classified as having MI. Positive TnI was independently associated with older age, hypertension, smoking, peripheral arterial disease, heart failure, higher systolic blood pressure, higher serum creatinine, and lower heart rate (P < .01). Patients with MI had the highest inpatient mortality (P < .001) and the lowest survival rate by Kaplan-Meier analysis (P < .0001). Peak TnI greater than or equal to 0.5 μg/L, particularly if satisfying criteria for MI, was independently associated with long-term mortality (P < .0001); peak TnI less than 0.5 μg/L alone was not when adjusted for covariates.

Conclusion

Positive TnI greater than or equal to 0.5 μg/L in patients with acute ischemic stroke was independently associated with worse outcomes. Patients with diagnosis of MI represent a particularly high-risk subgroup.