Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma
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- 作者：Bryan D. Choi ; Carter M. Suryadevara ; Patrick C. Gedeon ; James E. Herndon II ; Luis Sanchez-Perez ; Darell D. Bigner ; John H. Sampson
- 关键词：Central nervous system neoplasms ; Epidermal growth factor receptor ; Glioblastoma ; Immunotherapy ; T-lymphocytes
- 刊名：Journal of Clinical Neuroscience
- 出版年：January, 2014
- 年：2014
- 卷：21
- 期：1
- 页码：189-190
- 全文大小：358 K
文摘
Chimeric antigen receptors (CAR)-transduced T cells hold great promise in the treatment of malignant disease. Here, we demonstrate that intracerebral injection with a human, epidermal growth factor receptor variant III (EGFRvIII)-specific, third generation CAR successfully treats glioma in mice. Importantly, these results endorse clinical translation of this CAR in patients with EGFRvIII-expressing brain tumors.