C1473G polymorphism in mouse tryptophan hydroxylase-2 gene in the regulation of the reaction to emotional stress

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• 作者：Ekaterina Y. Bazhenova^a ; ^{Kata_Yurevna@mail.ru} ; Daria V. Bazovkina^b ; Elizabeth A. Kulikova^b ; Dariya V. Fursenko^a ; Nikita V. Khotskin^a ; Daria V. Lichman^c ; Alexander V. Kulikov^a
• 关键词：Stress ; Serotonin ; Tryptophan hydroxylase-2 gene ; C1473G polymorphism ; Mice
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：640
• 期：Complete
• 页码：105-110
• 全文大小：805 K
• 卷排序：640

文摘

C1473G polymorphism in Tph2 gene regulates enzyme activity in mouse brain. The stress-induced c-Fos mRNA rise is more intensive in the brain of B6-1473G mice. The polymorphism modifies the effect of stress on 5-HT metabolism in the hypothalamus.