Molecular mechanics-assisted crystal engineering of solid state photoreactions: application to the Yang photocyclization of ????-1-norbornylacetophenone derivatives
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- 作者：Botoshansky ; Mark ; Braga ; Dario ; Kaftory ; Menahem ; Maini ; Lucia ; Patrick ; Brian O. ; Scheffer ; John R. ; et. al.
- 关键词：Crystal engineering ; Solid state photochemistry ; Asymmetric induction ; Yang photocyclization ; X-ray crystallography ; Ionic chiral auxiliaries
- 刊名：Tetrahedron Letters
- 出版年：2005
- 出版时间：February 14, 2005
- 年：2005
- 卷：46
- 期：7
- 页码：1141-1144
- 全文大小：144 K
文摘
Based on molecular mechanics, Yang photocyclization of ??-1-norbornylacetophenone derivatives in the crystalline state was engineered through methylation adjacent to the carbonyl group, thus changing the conformation in the crystal and leading to enhanced diastereo- and enantioselectivity.