Mice as models of human developmental disorders: natural and artificial mutants
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- 作者：Darling ; Susan
- 关键词：cho chondrodysplasia ; Fgfr fibroblast growth factor receptor ; GABA γ ; -amino butyric acid ; Pdgfr platelet-derived growth factor receptor ; TGF-β ; 3 transforming growth factor-β ; 3
- 刊名：Current Opinion in Genetics & Development
- 出版年：1996
- 出版时间：June, 1996
- 年：1996
- 卷：6
- 期：3
- 页码：289-294
- 全文大小：599 K
文摘
Over the past year, the mouse has been used as a model to make significant contributions towards our understanding of human developmental disorders. The existence of both natural and artificial mouse mutants has not only facilitated the identification of mutations and provided candidate genes for human disorders but has also increased our knowledge regarding the cellular and molecular processes involved in normal mammalian embryogenesis.