50 studies (2828 patients) were included in final analysis. Presence of myoclonus at 24-48 h, bilateral absence of short-latency somatosensory evoked potential (SSEP) N20 wave at 24-72 h, absence of electroencephalographic activity >20-21 ¦ÌV ¡Ü72 h and absence of pupillary reflex at 72 h predicted CPC 4-5 with 0 % FPR and narrow (<10 % ) 95 % confidence intervals. Absence of SSEP N20 wave at 24 h predicted CPC 3-5 with 0 % [0-8] FPR. Serum thresholds for 0 % FPR of biomarkers neuron specific enolase (NSE) and S-100B were highly inconsistent among studies. Most of the studies had a low or very low QOE and did not report blinding of the treating team from the results of the investigated predictor.
In comatose resuscitated patients not treated with TH presence of myoclonus, absence of pupillary reflex, bilateral absence of N20 SSEP wave and low EEG voltage each predicted poor outcome early and accurately, but with a relevant risk of bias.