Geological CO2 sequestration may generate significant volumes of highly saline brine. Existing and emerging high-TDS desalination technologies are critically evaluated. Evaporators are identified as the most suitable existing technology. Mt. Simon brine treatment by multi-effect evaporation is modeled by Aspen simulation. Near-ZLD treatment of Mt. Simon brine requires 246xA0;kWh thermal energy per m3 of recovered water.