Baseline MAPK signaling activity confers intrinsic radioresistance to KRAS-mutant colorectal carcinoma cells by rapid upregulation of heterogeneous nuclear ribonucleoprotein K (hnRNP K)

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• 作者：Stefan Eder^a ; ^{stefanfriedricheder@bundeswehr.org} ; Annette Arndt^b ; Andreas Lamkowski^a ; Wassiliki Daskalaki^c ; Alexis Rump^a ; Markus Priller^a ; Felicitas Genze^d ; Eva Wardelmann^c ; Matthias Port^a ; Konrad Steinestel^b ; ^c
• 关键词：hnRNPK ; Colorectal carcinoma ; Ionizing radiation ; KRAS ; MEK inhibition
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：385
• 期：Complete
• 页码：160-167
• 全文大小：1984 K
• 卷排序：385

文摘

hnRNP K is overexpressed in colorectal carcinoma. KRAS-mutant CRC cells show intrinsic radioresistance and rapid upregulation of hnRNP K in response to IR. hnRNP K knockdown impairs cell survival and proliferation and increases apoptosis upon IR. MEK inhibition suppresses hnRNP K expression. MEK inhibition may confer radiosensitivity to primary radioresistant CRC cells.