Impact of Human Leukocyte Antigen Allele Mismatch in Unrelated Bone Marrow Transplantation with Reduced-Intensity Conditioning Regimen

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• 作者：Hisayuki Yokoyama¹ ; ^{yokoyamah@snh.go.jp} ; Junya Kanda² ; Shigeo Fuji³ ; Sung-Won Kim³ ; Takahiro Fukuda³ ; Yuho Najima⁴ ; Hitoshi Ohno⁵ ; Naoyuki Uchida⁶ ; Yasunori Ueda⁷ ; Tetsuya Eto⁸ ; Koji Iwato⁹ ; Hikaru Kobayashi¹⁰ ; Yukiyasu Ozawa¹¹ ; Tadakazu Kondo¹² ; Tatsuo Ichinohe¹³ ; Yoshiko Atsuta¹⁴ ; ¹⁵ ; Yoshinobu Kanda² ; ¹⁶ ; on behalf of the HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation
• 关键词：Reduced-intensity conditioning ; HLA mismatch ; Unrelated bone marrow transplantation
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：23
• 期：2
• 页码：300-309
• 全文大小：1532 K
• 卷排序：23

文摘

HLA 7/8 or 6/8–mismatched unrelated bone marrow transplantation with reduced-intensity conditioning was inferior to 8/8-matched unrelated bone marrow transplantation in overall survival The impact of HLA mismatch locus on overall survival was more pronounced in HLA-A, -B, -C than on DRB1. The difference of the impact among each HLA locus was reduced in the late time periods