Plasmonic nanoshells enhanced laser desorption/ionization mass spectrometry for detection of serum metabolites

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• 作者：Xiang Wei^a ; ¹ ; Zhonghui Liu^a ; ¹ ; Xiulong Jin^a ; Lin Huang^a ; Deepanjali Dattatray Gurav^a ; Xuming Sun^a ; Baohong Liu^b ; Jian Ye^a ; ^{yejian78@sjtu.edu.cn} ; Kun Qian^a ; ^{k.qian@sjtu.edu.cn}
• 关键词：Hot carriers ; Laser desorption/ionization mass spectrometry ; Plasmonic nanoparticles ; Metabolites ; Serum
• 刊名：Analytica Chimica Acta
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：950
• 期：Complete
• 页码：147-155
• 全文大小：1609 K
• 卷排序：950

文摘

The enhancement mechanism of laser desorption/ionization process is revealed by plasmonic particles with hot carriers. Superior analytical sensitivity and selectivity are achieved for detection of small metabolites over conventional matrices. The real case application of plasmonic particles is demonstrated in detection of serum samples towards clinical use.