Leptin regulates energy intake but fails to facilitate hibernation in fattening Daurian ground squirrels (Spermophilus dauricus)
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- 作者：Xin Xinga ; c ; Gang-Bin Tanga ; Ming-Yue Sunb ; Chao Yub ; Shi-Yi Songb ; Xin-Yu Liub ; Ming Yangb ; yangming@synu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; De-Hua Wanga ; wangdh@ioz.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hibernation ; Leptin ; Fattening ; Daurian ground squirrels (Spermophilus dauricus)
- 刊名：Journal of Thermal Biology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：57
- 期：Complete
- 页码：35-43
- 全文大小：1997 K
文摘
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ICV leptin administration suppressed the hyperphagia and body mass gain of fattening Daurian ground squirrel.
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Hypothalamic NPY and AgRP would be involved in this leptin-mediated decrease of food intake in fattening squirrels.
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As an adipose signal, elevated leptin level fails to induce fattening squirrels to enter into hibernation.
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UCP1 in BAT, the crucial thermogenesis protein for mammals, was not regulated by the variation of leptin in Daurian ground squirrel.