Diverse modes of NMDA receptor positive allosteric modulation: Mechanisms and consequences
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- 作者：David H. Hackos ; hackos.david@gene.com" class="auth_mail" title="E-mail the corresponding author ; Jesse E. Hanson ; hanson.jesse@gene.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：PYD-106 ; CIQ ; Spermine ; Pregnenolone ; GNE-6901 ; GNE-8324 ; TCN-201 ; SGE201 ; SGE301 ; Schizophrenia
- 刊名：Neuropharmacology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：112
- 期：part_PA
- 页码：34-45
- 全文大小：1410 K
文摘
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NMDAR PAMs work by either increasing maximal current (type I effect) or decreasing agonist EC50 (type II effect), or both.
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Several chemically distinct classes of NMDAR PAMs with distinct binding sites and modes of action are described.
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Potential consequences of different types of PAM effects on brain function (desirable and undesirable) are considered.