Molecular Insights into the Enigmatic Metabolic Regulator, SnRK1

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• 作者：Shane Emanuelle¹ ; Monika S. Doblin¹ ; David I. Stapleton² ; Antony Bacic¹ ; ^{abacic@unimelb.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Paul R. Gooley³
• 关键词：SNF1-related kinase 1 (SnRK1) ; sucrose non-fermenting 1 (SNF1) ; AMP-activated protein kinase (AMPK) ; plant metabolic control ; phosphorylation ; trehalose-6-phosphate (T6P)
• 刊名：Trends in Plant Science
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：21
• 期：4
• 页码：341-353
• 全文大小：2495 K

文摘

Sucrose non-fermenting-1 (SNF1)-related kinase 1 (SnRK1) lies at the heart of metabolic homeostasis in plants and is crucial for normal development and response to stress. Evolutionarily related to SNF1 in yeast and AMP-activated kinase (AMPK) in mammals, SnRK1 acts protectively to maintain homeostasis in the face of fluctuations in energy status. Despite a conserved function, the structure and regulation of the plant kinase differ considerably from its relatively well-understood opisthokont orthologues. In this review, we highlight the known plant-specific modes of regulation involving SnRK1 together with new insights based on a 3D molecular model of the kinase. We also summarise how these differences from other orthologues may be specific adaptations to plant metabolism, and offer insights into possible avenues of future inquiry into this enigmatic enzyme.