Genomic Alterations in CIITA Are Frequent in Primary Mediastinal Large B Cell Lymphoma and Are Associated with Diminished MHC Class II Expression
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- 作者：Anja Mottok1 ; 2 ; 6 ; Bruce Woolcock1 ; 6 ; Fong Chun Chan1 ; 3 ; King Mong Tong1 ; Lauren Chong1 ; 3 ; Pedro Farinha1 ; Adè ; le Telenius1 ; Elizabeth Chavez1 ; Suvan Ramchandani1 ; Marie Drake1 ; Merrill Boyle1 ; Susana Ben-Neriah1 ; David W. Scott1 ; Lisa M. Rimsza4 ; Reiner Siebert5 ; Randy D. Gascoyne1 ; 2 ; Christian Steidl1 ; 2 ; csteidl@bccancer.bc.ca" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：17 November 2015
- 年：2015
- 卷：13
- 期：7
- 页码：1418-1431
- 全文大小：3888 K
文摘
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CIITA is frequently mutated in PMBCL
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CIITA is a target of AID-mediated aberrant somatic hypermutation
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Genomic alterations of CIITA result in reduced MHC class II expression
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CIITA loss of function confers an immune privilege phenotype in PMBCL