Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers
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- 作者：Leonard D. Goldstein1 ; 3 ; 7 ; James Lee2 ; 7 ; Florian Gnad3 ; Christiaan Klijn3 ; Annalisa Schaub2 ; 8 ; Jens Reeder3 ; Anneleen Daemen3 ; Corey E. Bakalarski3 ; 4 ; Thomas Holcomb5 ; David S. Shames5 ; Ryan J. Hartmaier6 ; Juliann Chmielecki6 ; Somasekar Seshagiri1 ; Robert Gentleman3 ; 9 ; David Stokoe2 ; 10 ; stokoe.david@gene.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：16
- 期：10
- 页码：2605-2617
- 全文大小：3127 K
文摘
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Recurrent removal of NFE2L2 exon 2 occurs in lung cancers and head and neck cancers
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Exon removal results in Nrf2 stabilization and downstream pathway activation
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Exon deletions explain Nrf2 activation in patients without mutations in Nrf2 or KEAP1