Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming
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- 作者：Young Chan Chae1 ; Valentina Vaira2 ; 3 ; 4 ; M. Cecilia Caino1 ; Hsin-Yao Tang4 ; Jae Ho Seo1 ; Andrew V. Kossenkov5 ; Luisa Ottobrini4 ; 6 ; Cristina Martelli4 ; Giovanni Lucignani7 ; 8 ; Irene Bertolini3 ; 4 ; Marco Locatelli9 ; Kelly G. Bryant1 ; Jagadish C. Ghosh1 ; Sofia Lisanti1 ; Bonsu Ku10 ; Silvano Bosari3 ; 4 ; Lucia R. Languino11 ; David W. Speicher5 ; 12 ; Dario C. Altieri1 ; daltieri@wistar.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：mitochondria ; Akt ; PDK1 ; hypoxia ; metabolism ; tumor cell proliferation
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：8 August 2016
- 年：2016
- 卷：30
- 期：2
- 页码：257-272
- 全文大小：6631 K
文摘
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A pool of active Akt is recruited to tumor mitochondria during hypoxia
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Mitochondrial Akt phosphorylates PDK-1 in hypoxia on a T346 site
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Akt-PDK1 activation maintains tumor cell proliferation in hypoxia
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PDK1 phosphorylation by Akt is a negative prognostic factor in gliomas