Mapping effective connectivity in the human brain with concurrent intracranial electrical stimulation and BOLD-fMRI

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• 作者：Hiroyuki Oya^a ; ^{hiroyuki-oya@uiowa.edu} ; Matthew A. Howard^a ; Vincent A. Magnotta^b ; Anton Kruger^c ; Timothy D. Griffiths^d ; Louis Lemieux^e ; David W. Carmichael^f ; Christopher I. Petkov^d ; Hiroto Kawasaki^a ; Christopher K. Kovach^a ; Matthew J. Sutterer^a ; Ralph Adolphs^g
• 关键词：Effective connectivity ; Human ; Electrical stimulation ; Functional MRI ; DBS ; Amygdala
• 刊名：Journal of Neuroscience Methods
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：277
• 期：Complete
• 页码：101-112
• 全文大小：3662 K
• 卷排序：277

文摘

We developed safe and reliable protocol for concurrent intracranial electrical stimulation and functional MRI (es-fMRI) in awake human subjects at 3 T. No adverse effect was observed in our series of 16 subjects who underwent es-fMRI experiment. We compared the es-fMRI effective connectivity with functional connectivity informed by resting-state fMRI and showed both are not redundant and may carries complimentary information about the brain’s connectivity.