Primary blast injury causes cognitive impairments and hippocampal circuit alterations
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- 作者：Matthew Beamera ; 1 ; Shanti R. Tummalaa ; 1 ; David Gullottia ; Catherine Kopila ; Samuel Gorkaa ; Ted Abelb ; Cameron R. &ldquo ; Dale&rdquo ; Bassf ; Barclay Morrison IIIg ; Akiva S. Cohend ; e ; David F. Meaneya ; c ; dmeaney@seas.upenn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Blast induced traumatic brain injury ; Concussion ; Blood-brain barrier
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：283
- 期：part_PA
- 页码：16-28
- 全文大小：2221 K
文摘
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The effects of a primary blast load applied on the mouse brain are isolated.
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Performance in a spatial object recognition task and open field is impaired.
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Network excitability in area CA1 is decreased and inhibition is augmented.
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Increased gliosis (GFAP and Iba1 staining) appear in the hippocampus.
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Blast induced changes in brain function were independent of overpressure.