Activation of 5-hyrdoxytryptamine 7 receptors within the rat nucleus tractus solitarii modulates synaptic properties
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- 作者：Michael P. Matott1 ; matottm@missouri.edu" class="auth_mail" title="E-mail the corresponding author ; David D. Kline ; 1 ; klinedd@missouri.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Serotonin receptors ; Autonomic nervous system ; Patch clamp ; EPSC ; IPSC ; Respiration
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：1635
- 期：Complete
- 页码：12-26
- 全文大小：980 K
文摘
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Activation of nTS 5-HT7 receptors produces both inhibitory and excitatory responses.
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Paired pulse ratio increased with LP 44, suggesting pre-synaptic action for 5-HT7R.
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5-HT7R activation reduces mEPSC frequency and modulates GABA effect on nTS neurons.
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Co-blockade of 5-HT7&1ARs reduces peak amplitude of evoked TS currents.