PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo
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- 作者：Joseph Ochaba1 ; Alex Mas Monteys2 ; Jacqueline G. O&rsquo ; Rourke3 ; Jack C. Reidling4 ; Joan S. Steffan4 ; 5 ; Beverly L. Davidson2 ; 6 ; Leslie M. Thompson1 ; 4 ; 5 ; lmthomps@uci.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：4 May 2016
- 年：2016
- 卷：90
- 期：3
- 页码：507-520
- 全文大小：3614 K
文摘
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Reducing PIAS1 levels rescues mHTT-associated phenotypes in R6/2 mice
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Striatal modulation of PIAS1 alters insoluble mHTT, SUMO, and ubiquitin accumulation
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PIAS1 reduction normalizes inflammatory homeostasis of key markers in R6/2 striatum
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PIAS1 overexpression exacerbates mHTT-associated phenotypes