MMP-7 is a highly specific negative marker for benign and malignant mesothelial cells in serous effusions

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• 作者：Ben Davidson ; MD ; PhD^a ; ^b ; ^{bend@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author} ; Helene Tuft Stavnes ; MSc^a ; Ellen Hellesylt ; MSc^a ; Thomas Hager ; MD^c ; Pio Zeppa ; MD ; PhD^d ; Maurizio Pinamonti ; MD^e ; Jeremias Wohlschlaeger ; MD ; PhD^c
• 关键词：MMP-7 ; Effusions ; Carcinoma ; Mesothelioma ; Reactive mesothelial cells ; Diagnosis
• 刊名：Human Pathology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：47
• 期：1
• 页码：104-108
• 全文大小：490 K

文摘

The aim of this study was to analyze the diagnostic role of MMP-7 in effusion cytology. Effusions (n = 356), consisting of 307 carcinomas (184 ovarian, 55 breast, 32 lung, 36 carcinomas of other origin) and 49 malignant mesotheliomas, were analyzed for MMP-7 expression using immunohistochemistry. MMP-7 was expressed in 124/307 (40%) carcinomas and was uniformly absent in malignant mesotheliomas (0/49; 0%; P < .001). Reactive mesothelial cells were similarly MMP-7 negative in all carcinoma specimens. In carcinomas, expression was most frequent in tumors of ovarian and other female genital (cervical and endometrial) origin (P < .001). The sensitivity and specificity of this marker in the differential diagnosis between high-grade serous carcinoma and malignant mesothelioma were 46% and 100%, respectively. In conclusion, MMP-7 expression is highly specific, though only of moderate sensitivity, for the diagnosis of carcinoma in the differential diagnosis from both benign and malignant mesothelial cells.