In vitro Etest synergy of doripenem with amikacin, colistin, and levofloxacin against Pseudomonas aeruginosa with defined carbapenem resistance mechanisms as determined by the Etest method

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• 作者：Wendy He ; ^{WHe8@its.jnj.com} ; Koné ; Kaniga ; A. Simon Lynch ; Robert K. Flamm¹ ; Todd A. Davies
• 关键词：Doripenem ; Pseudomonas aeruginosa ; Etest ; Synergy ; Combination
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：74
• 期：4
• 页码：417-419
• 全文大小：134 K

文摘

The applicability of Etest for synergy testing was evaluated in 100 carbapenem-nonsusceptible Pseudomonas aeruginosa isolates. Combinations of doripenem with amikacin, colistin, or levofloxacin were synergistic or additive against 67 % , 31 % , and 23 % of isolates, respectively. The use of Etest was practical to evaluate the synergy of doripenem with other antipseudomonal agents.