Ultrasensitive electrochemical aptasensor for the detection of thrombin based on dual signal amplification strategy of Au@GS and DNA-CoPd NPs conjugates
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- 作者：Yaoguang Wanga ; Yong Zhanga ; Tao Yanb ; Dawei Fana ; Bin Dua ; b ; Hongmin Maa ; mahongmin2002@126.com" class="auth_mail" title="E-mail the corresponding author ; Qin Weia
- 关键词：Electrochemical aptasensor ; Sandwich-type ; Thrombin ; Au@graphene sheet ; CoPd nanoparticles
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：80
- 期：Complete
- 页码：640-646
- 全文大小：1423 K
文摘
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An ultrasensitive electrochemical aptasensor was developed for detecting thrombin.
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Au@GS added the loading amount of Apt1 and facilitated the electron transfer.
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CoPd NPs were used to label Apt2 for the first time.
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The aptasensor displayed low detection limit of 5.0 pg/mL for thrombin.