Inhibition of the formation of benzo[a]pyrene adducts to DNA in A549 lung cells exposed to mixtures of polycyclic aromatic hydrocarbons
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- 作者：Camille Geniesa ; b ; c ; Amandine Julliena ; b ; Emmanuel Lefebvrea ; b ; c ; Morgane Revola ; b ; Anne Maitrec ; Thierry Doukia ; b ; thierry.douki@cea.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：B[a]A ; benz[a]anthracene ; B[a]P ; benzo[a]pyrene ; B[b]F ; benzo[b]fluoranthene ; B[e]P ; benzo[e]pyrene ; B[ghi]P ; benzo[g ; h ; i]perylene ; B[j]F ; benzo[j]fluoranthene ; B[k]F ; benzo[k]fluoranthene ; BPDE ; benzo[a]pyrene diol epoxide ; Chrys ; chrysene ; CYP450 ; cytochrome P450 ; DB[ah]A ; dibenz[a ; h]anthracene ; EROD ; ethoxyresorufin-O-deethylase ; Flua ; fluoranthene ; HPLC-MS/MS ; high performance liquid chromatography coupled to tandem mass spectrometry ; IP ; indeno[1 ; 2 ; 3-cd]pyrene ; MTT ; 3-(4.5-Dimethylthiazol-2
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：35
- 期：Complete
- 页码：1-10
- 全文大小：805 K
文摘
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The carcinogenic potency of PAHs correlates with the induction of CYP450 genes in A549 cells.
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The most carcinogenic PAHs inhibit the formation of B[a]P adducts in binary mixtures.
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A synergistic effect is for gene induction observed in A549 exposed to complex mixtures.
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Both EROD activity and DNA adducts formation are inhibited by complex mixtures in A549 cells.
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These results questions the risk assessment strategies based on additivity of effects.