We first confirmed the expression and function of long noncoding RNA maternally expressed gene 3 (MEG3) in ischemia.
MEG3 binds with p53-DBD271–282 which stimulates p53-mediated transactivation and mediates ischemic neuronal death.
Intervention of MEG3–p53 interaction by administration of Tat-p53-DBD271–282 protects against ischemic insults.