Asymmetric ¦Á-hydroxy ketone synthesis by direct ketone oxidation using a bimetallic palladium(II) complex

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• 作者：Othman A. Hamed^a ; Arab El-Qisairi^b ; Hanan Qaseer^b ; Emad M. Hamed^c ; ^&dagger ; ; Patrick M. Henry^d ; ^?/sup> ; Daniel P. Becker^d ; ^{dbecke3@luc.edu}
• 关键词：Asymmetric synthesis ; ¦Á-Hydroxyketone ; Palladium catalysis ; Acyloin ; Bimetallic palladium
• 刊名：Tetrahedron Letters
• 出版年：2012
• 出版时间：30 May, 2012
• 年：2012
• 卷：53
• 期：22
• 页码：2699-2701
• 全文大小：265 K

文摘

The oxidation of ketones by a chiral bimetallic palladium(II) complex in the presence of CuCl₂ in THF-water solvents gave an enantioselective synthesis of ¦Á-hydroxyketones in catalytic oxidation utilizing an atmosphere of oxygen. The ee¡¯s ranged from 61 % to 92 % . The reaction was accelerated by addition of strong acid that presumably increases the rate of enolization.