Small-molecule probe using dual signals to monitor leucine aminopeptidase activity

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• 作者：Hey Young Yoon^a ; So Hee Shim^b ; Luck Ju Baek^b ; Jong-In Hong^a ; ^{jihong@snu.ac.kr}
• 关键词：Leucine aminopeptidases ; Probe ; Dual signals ; 2-Dicyanomethylene-3-cyano-2 ; 5-dihydrofuran (DCDHF) unit
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2011
• 出版时间：15 April, 2011
• 年：2011
• 卷：21
• 期：7
• 页码：2403-2405
• 全文大小：1K

文摘

Leucine aminopeptidases (LAPs) are widely distributed in organisms from bacteria to humans, and play crucial roles in cell maintenance and cell growth. Thus, assays for LAP are necessary for measuring its activity and inhibitor potency. In this Letter, we report a small-molecule probe which exhibits colorimetric and fluorogenic changes according to LAP activity.