Comparative genomics analysis of mononuclear phagocyte subsets confirms homology between lymphoid tissue-resident and dermal XCR1+ DCs in mouse and human and distinguishes them from Langerhans cells
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- 作者：Sabrina Carpentiera ; 1 ; Thien-Phong Vu Manhb ; 1 ; Rabie Chelbib ; Sandrine Henrib ; Bernard Malissenb ; Muzlifah Haniffac ; m.a.haniffa@newcastle.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Florent Ginhouxd ; Florent_Ginhoux@immunol.a-star.edu.sg" class="auth_mail" title="E-mail the corresponding author ; Marc Dalodb ; dalod@ciml.univ-mrs.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：CLN_migDCs ; cutaneous lymph node migratory dendritic cells ; DC ; dendritic cells ; DDCs ; dermal dendritic cells ; DMPs ; dermal mononuclear phagocytes ; FDR ; false discovery rate ; GSEA ; gene set enrichment analysis ; LCs ; Langerhans cells ; LT-DCs ; lymphoid tissue-resident dendritic cells ; Mac ; macrophages ; Mo ; monocytes ; MoDCs ; monocyte-derived dendritic cells ; MPs ; mononuclear phagocytes ; NES ; normalized enrichment score ; PCA ; principal component analysis
- 刊名：Journal of Immunological Methods
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：432
- 期：Complete
- 页码：35-49
- 全文大小：4752 K
文摘
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Rigorous phenotypic identification of human CD141highXCR1+ dermal DCs is challenging.
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Comparative genomics enables rigorous identification of cell populations.
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Human dermal CD141highXCR1+ DCs are homologous to human blood and mouse XCR1+ DCs.
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Human Langerhans cells are homologous to mouse Langerhans cells.
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Langerhans cells selectively express DC rather than macrophage gene signatures.