The histone deacetylase inhibitor sodium butyrate improves insulin signalling in palmitate-induced insulin resistance in L6 rat muscle cells through epigenetically-mediated up-regulation of Irs1
Sodium butyrate (NaBut) is a histone deacetylase (HDAC) inhibitor. NaBut ameliorates the insulin-resistant phenotype, induced by prolonged exposure to palmitate in L6 muscle cells. NaBut improves insulin-induced phosphorylation of PKB and MAPK in insulin-resistant cells. NaBut causes histone H3 hyperacetylation on chromatin in proximity of the Irs1 transcriptional start site. NaBut promotes insulin responsiveness in L6 myotubes under conditions of lipid-induced insulin resistance.